HORDB

ID: hor006536
Uniprot ID: P22642
Protein name: Ventricular natriuretic peptide
Gene name: vnp
Organism: Anguilla japonica (Japanese eel)
Family: Natriuretic peptide family
Source: animal
Expression: Heart ventricle, and to a lower extent in heart atrium.
Disease: NA
Comments: NA
Taxonomy: Anguilla (genus), Anguillidae (family), Anguilliformes (order), Elopomorpha , Elopocephala , Elopocephalai , Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Sequence: KSFNSCFGTRMDRIGSWSGLGCNSLKNGTKKKIFGN
Length: 36
Propeptide: MAKSGIYLGCFILILIQNMVAANPLFNRNNVQELENLKDLIHQLEERVAVNEEPEVYPESEDMKMDAEEEDAGISPGALRQSEENLLMNIVDRIAPESPLRSRFRDLAGLAKTAKSFNSCFGTRMDRIGSWSGLGCNSLKNGTKKKIFGN
Signal peptide: MAKSGIYLGCFILILIQNMVA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006536_AF2.pdb

hor006536_ESM.pdb

Mass:	456498	Formula:	C170H272N52O50S3
Absent amino acids:	AEHPQVY	Common amino acids:	G
pI:	10.96	Basic residues:	7
Polar residues:	19	Hydrophobic residues:	8
Hydrophobicity:	-63.33	Boman Index:	-7351
Half-Life:	1.3 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	43.33
Instability Index:	21.67	Extinction Coefficient cystines:	5625
Absorbance 280nm:	160.71

PubMed ID: 7893352
Title: Eel ventricular natriuretic peptide: cDNA cloning and mRNA expression.
PubMed ID: 1828035
Title: A novel natriuretic peptide isolated from eel cardiac ventricles.